moleculardna/include/DamageModel.hh

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0025 //
0026 //
0027 /// file: DamageModel.hh
0028 /// brief: Parameters related to the DNA Damage model
0029 #ifndef MOLECULAR_DAMAGE_MODEL
0030 #define MOLECULAR_DAMAGE_MODEL
0031
0032 #include "DamageModelMessenger.hh"
0033
0034 #include "G4Electron_aq.hh"
0035 #include "G4Hydrogen.hh"
0036 #include "G4MolecularConfiguration.hh"
0037 #include "G4OH.hh"
0038 #include "G4SystemOfUnits.hh"
0039 #include "Randomize.hh"
0040 #include "globals.hh"
0041
0042 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo......
0043
0044 class DamageModel
0045 {
0046   public:
0047     DamageModel();
0048
0049     virtual ~DamageModel() { delete fpDamageMessenger; };
0050
0051     // methods
0052     G4bool IsDirectStrandBreak(const G4double&) const;
0053
0054     G4bool IsIndirectStrandDamage(const G4MolecularConfiguration*) const;
0055
0056     G4bool IsIndirectBaseDamage(const G4MolecularConfiguration*) const;
0057
0058     G4bool IsInducedStrandBreak(const G4MolecularConfiguration*) const;
0059
0060     // setters
0061     void SetDirectDamageLower(G4double d)
0062     {
0063       fDirectDmgLower = d;
0064       if (fDirectDmgLower < fDirectDmgUpper) fDirectDmgUpper = fDirectDmgLower;
0065     };
0066
0067     void SetDirectDamageUpper(G4double d)
0068     {
0069       fDirectDmgUpper = d;
0070       if (fDirectDmgLower > fDirectDmgUpper) fDirectDmgLower = fDirectDmgUpper;
0071     };
0072
0073     // Indirect OH
0074     void SetIndirectOHStrandChance(G4double d)
0075     {
0076       CheckValidProbability("DamageStrandOH", d);
0077       fStrandOH = d;
0078     }
0079
0080     void SetIndirectOHBaseChance(G4double d)
0081     {
0082       CheckValidProbability("DamageBaseOH", d);
0083       fBaseOH = d;
0084     }
0085
0086     void SetInductionOHChance(G4double d)
0087     {
0088       CheckValidProbability("InductionOH", d);
0089       fInductionOH = d;
0090     };
0091
0092     // Indirect Eaq
0093     void SetIndirectEaqStrandChance(G4double d)
0094     {
0095       CheckValidProbability("DamageStrandEaq", d);
0096       fStrandEaq = d;
0097     }
0098
0099     void SetIndirectEaqBaseChance(G4double d)
0100     {
0101       CheckValidProbability("DamageBaseEaq", d);
0102       fBaseEaq = d;
0103     }
0104
0105     void SetInductionEaqChance(G4double d)
0106     {
0107       CheckValidProbability("InductionEaq", d);
0108       fInductionEaq = d;
0109     };
0110
0111     // Indirect H
0112     void SetIndirectHStrandChance(G4double d)
0113     {
0114       CheckValidProbability("DamageStrandH", d);
0115       fStrandH = d;
0116     }
0117
0118     void SetIndirectHBaseChance(G4double d)
0119     {
0120       CheckValidProbability("DamageBaseH", d);
0121       fBaseH = d;
0122     }
0123
0124     void SetInductionHChance(G4double d)
0125     {
0126       CheckValidProbability("InductionH", d);
0127       fInductionH = d;
0128     };
0129
0130   protected:
0131     static void CheckValidProbability(const G4String& str, G4double p);
0132
0133   private:
0134     DamageModelMessenger* fpDamageMessenger;
0135     G4double fDirectDmgLower = 17.5 * eV, fDirectDmgUpper = 17.5 * eV;
0136     G4double fInductionOH = 0, fInductionEaq = 0, fInductionH = 0;
0137     G4double fStrandOH = 1.0, fStrandEaq = 1.0, fStrandH = 1.0;
0138     G4double fBaseOH = 1.0, fBaseEaq = 1.0, fBaseH = 1.0;
0139     const G4MoleculeDefinition* fOH = G4OH::Definition();
0140     const G4MoleculeDefinition* fe_aq = G4Electron_aq::Definition();
0141     const G4MoleculeDefinition* fH = G4Hydrogen::Definition();
0142 };
0143
0144 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo......
0145
0146 #endif  // MOLECULAR_DAMAGE_MODEL