EIC code displayed by LXR master/​geant4/​examples/​advanced/​dna/​dsbandrepair/​analysis/​dnadamage/​src/​ScanDamage.cc	Source navigation Diff markup Identifier search General search
	Version: master test Revert   Change

File indexing completed on 2025-10-14 08:06:13

 //
 // ********************************************************************
 // * License and Disclaimer                                           *
 // *                                                                  *
 // * The  Geant4 software  is  copyright of the Copyright Holders  of *
 // * the Geant4 Collaboration.  It is provided  under  the terms  and *
 // * conditions of the Geant4 Software License,  included in the file *
 // * LICENSE and available at  http://cern.ch/geant4/license .  These *
 // * include a list of copyright holders.                             *
 // *                                                                  *
 // * Neither the authors of this software system, nor their employing *
 // * institutes,nor the agencies providing financial support for this *
 // * work  make  any representation or  warranty, express or implied, *
 // * regarding  this  software system or assume any liability for its *
 // * use.  Please see the license in the file  LICENSE  and URL above *
 // * for the full disclaimer and the limitation of liability.         *
 // *                                                                  *
 // * This  code  implementation is the result of  the  scientific and *
 // * technical work of the GEANT4 collaboration.                      *
 // * By using,  copying,  modifying or  distributing the software (or *
 // * any work based  on the software)  you  agree  to acknowledge its *
 // * use  in  resulting  scientific  publications,  and indicate your *
 // * acceptance of all terms of the Geant4 Software license.          *
 // ********************************************************************
 //
 //
 /// \file ScanDamage.cc
 /// \brief Implementation of the ScanDamage class
 
 #include "ScanDamage.hh"
 #include "ParametersParser.hh"
 
 #include "TSystemDirectory.h"
 #include "TFile.h"
 #include "TTree.h"
 #include "TRandom.h"
 
 
 #include <iostream>
 #include <fstream>
 #include <sstream>
 #include <iostream>
 #include <filesystem>
 namespace fs = std::filesystem;
 TRandom gRandomGen; 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 ScanDamage::ScanDamage(): fSkipScanningIndirectDamage(false)
 {
     fThresholdEnergy = 17.5; //eV
     fEdepSumInNucleus = 0;
     fProbabilityForIndirectSB = 0.40; // 40%
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 std::map<unsigned int,std::map<unsigned int,std::vector<Damage> > > ScanDamage::ExtractDamage(){
     ReadCellandVoxelDefFilePaths();
     fMergedTables.clear();
     fDamage.clear();
     RetrieveVoxelBp();
     FillVoxelData();
     ScanDamageFromPhys();
     if (!fSkipScanningIndirectDamage) ScanDamageFromChem();
     MergeDamageFromPhysChem();
     for (const auto& [pChrom,table] : fMergedTables) {
         unsigned int evt;
         unsigned int strand;
         ullint cpyNb;
         unsigned int isBase;
         double time;
         double edep;
         double origin;
         Damage::DamageType pType;
         Damage::DamageCause pOrigin;
         std::map<unsigned int,std::vector<Damage> > perChromoDamage;
         for (const auto& v : table) {
             evt = v.at(0);
             strand = v.at(1);
             cpyNb = v.at(2);
             isBase = v.at(3);
             time = v.at(4);
             edep = v.at(5);
             origin = v.at(6);
             if(isBase==0)
                 pType=Damage::DamageType::fBackbone;
             else
                 pType=Damage::DamageType::fBase;
             if(origin==0)
                 pOrigin=Damage::DamageCause::fDirect;
             else
                 pOrigin=Damage::DamageCause::fIndirect;
             if (perChromoDamage.find(evt) == perChromoDamage.end()) {
                 std::vector<Damage> dm{Damage(pType,pChrom,evt,strand,cpyNb,Position(0,0,0),
                                             pOrigin,Damage::DamageChromatin::fUnspecified)};
                 perChromoDamage.insert({evt,dm});
             } else perChromoDamage[evt].push_back(Damage(pType,pChrom,evt,strand,cpyNb,Position(0,0,0),
                                             pOrigin,Damage::DamageChromatin::fUnspecified));
         }
         fDamage.insert({pChrom,perChromoDamage});
     }
     return fDamage;
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::RetrieveVoxelBp()
 {
     fBpPerVoxel.clear();
     
     for (const auto & entry : fVoxelDefFilesList) {
         std::ifstream file(entry);
         if(!file.good() )
         {
             std::cerr<<"**** Fatal Error *****"<<std::endl;
             std::cerr<<"ScanDamage::RetrieveVoxelBp: No file named "<<entry<<std::endl;
             std::cerr<<"*************** *****"<<std::endl;
             exit(EXIT_FAILURE);
         }
         std::string voxelName = "noName";
         std::string line;
         bool foundName = false;
         bool foundNumOfBp = false;
         while(std::getline(file, line)
             && !foundNumOfBp)
         {
             std::istringstream iss(line);
             std::string flag;
             iss >> flag;
             std::string charac;
             iss >> charac;
             // Look for the name of the voxel
             if(flag=="_Name")
             {
                 voxelName = charac;
                 foundName = true;
             }
             // Look for the flag "_Number"
             // And the characteristic "voxelBasePair"
             if(flag=="_Number" && charac=="voxelBasePair")
             {
                 int numOfBp;
                 iss >> numOfBp;
                 if(!foundName)
                 {
                     std::cerr<<"*** Fatal Error ***"<<std::endl;
                     std::cerr<<"ScanDamage::RetrieveVoxelBp: The number of bp was found before the name "
                     <<"of the voxel... This is an unexpected case."<<std::endl;
                     std::cerr<<"******"<<std::endl;
                     exit(EXIT_FAILURE);
                 }
                 else
                 {
                     fBpPerVoxel[voxelName] = numOfBp;
                     std::cout<<voxelName<<" has "<<numOfBp<<" bp"<<std::endl;
                     foundNumOfBp = true;
                 }
             }
         }
         file.close();
     }
     
     if (fBpPerVoxel.size() == 0) {
         std::cerr<<"**** Fatal Error *****"<<std::endl;
         std::cerr<<"ScanDamage::RetrieveVoxelBp: No Bp found in voxel definition files. \n Or make"
         <<" sure that file imp.info exists in working directory!"<<std::endl;
         std::cerr<<"*************** *****"<<std::endl;
         exit(EXIT_FAILURE);
     }
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::FillVoxelData()
 {   
     std::ifstream file(fCellDefFilePath);
     if(!file.good() )
     {
         std::cerr<<"**** Fatal Error *****"<<std::endl;
         std::cerr<<"FillVoxelData: No file named "<<fCellDefFilePath<<std::endl;
         std::cerr<<"*************** *****"<<std::endl;
         exit(EXIT_FAILURE);
     }
     ullint bpCount = 0;
     unsigned int voxelCount = 0;
     int chromo_previous = 0;
     // Read the file line by line
     std::string line;
     while(std::getline(file, line) )
     {
         std::istringstream iss(line);
         std::string flag;
         iss >> flag;
         // If the flag correspond to the placement of a voxel
         if(flag == "_pl")
         {
             std::string voxelName;
             iss >> voxelName;
             int chromo;
             iss >> chromo;
             int domain;
             iss >> domain;
             // If we change of chromosome then reset the number of bp.
             // Each chromosome starts at 0 bp.
             if(chromo != chromo_previous)
             {
                 bpCount = 0;
                 chromo_previous = chromo;
             }
             // Fill the data structure
             fVoxels.push_back( VoxelData(chromo, domain, bpCount) );
             int numBpinthisvoxel = int(fBpPerVoxel[voxelName]);
             bpCount += numBpinthisvoxel;
             if (fChromosomeBpMap.find(chromo) == fChromosomeBpMap.end()) {
                 fChromosomeBpMap.insert({chromo,numBpinthisvoxel});
             } else {
                 fChromosomeBpMap[chromo] += numBpinthisvoxel;
             }
             voxelCount++;
         }
     }
     file.close();
     
 
     if (fVoxels.size() == 0) {
         std::cerr<<"**** Fatal Error *****"<<std::endl;
         std::cerr<<"ScanDamage::FillVoxelData: NofVoxels info found in files "<<fCellDefFilePath<<std::endl;
         std::cerr<<"*************** *****"<<std::endl;
         exit(EXIT_FAILURE);
     }
     std::cout<<"Num of voxels: "<< fVoxels.size()<<" placed in Cell Nucleus."<<std::endl;
     std::cout<<"=====Choromosome sizes====="<<std::endl;
     std::cout<<"Chromosome ID\t Number of Bp"<<std::endl;
     for (auto const& [chrom, nBp] : fChromosomeBpMap) {
          std::cout<<chrom<< "\t"<<nBp<<std::endl;
     }
     std::cout<<"==========================="<<std::endl;
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::ScanDamageFromPhys()
 {
     std::cout<<"===== Start Scanning Damages From Phys =====\n";
     fEdepSumInNucleus = 0;
     fphysTables.clear();
     fphysSlectedTables.clear();
     fs::path currentP{"phys_output"};
     fs::file_status s = fs::file_status{};
     auto isExist = fs::status_known(s) ? fs::exists(s) : fs::exists(currentP);
     if (isExist) {
         bool isFoundRootFiles = false;
         for (const auto entry : fs::directory_iterator(currentP)) {
             if (entry.path().extension() == ".root") {
                 std::cout <<"ScanDamageFromPhys(): Processing file: "<< entry.path().filename()<< std::endl;
                 AnaPhysRootFile(entry.path());
                 if (!isFoundRootFiles) isFoundRootFiles=true;
             }
         }
         if (!isFoundRootFiles) {
             std::cout<<"=====>> No root files found in folder \"phys_ouput\"!!! Skip Scanning Damages From Phys =====\n";
         }
         if (fphysTables.size() > 0) {
             SortPhysTableWithSelection();
         }
     } else {
         std::cout<<"=====>> Cannot find folder \"phys_ouput\"!!! Skip Scanning Damages From Phys =====\n";
     }
 
     std::cout<<"===== End Scanning Damages From Phys =====\n";
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::ScanDamageFromChem()
 {
     std::cout<<"===== Start Scanning Damages From Chem =====\n";
     std::string fChemOutFolderName = ParametersParser::Instance()->GetChemOutFolderName();
     if (fChemOutFolderName == "") fChemOutFolderName = "chem_output";
     fs::path currentP{fChemOutFolderName};
     fs::file_status s = fs::file_status{};
     auto isExist = fs::status_known(s) ? fs::exists(s) : fs::exists(currentP);
     if (isExist) {
         bool isFoundRootFiles = false;
         for (const auto entry : fs::directory_iterator(currentP)) {
             if (entry.path().extension() == ".root") {
                 AnaChemRootFile(entry);
                 if (!isFoundRootFiles) isFoundRootFiles=true;
             }
         }
         if (!isFoundRootFiles) {
             std::cout<<"=====>> No root files found in folder \""<<fChemOutFolderName<<"\"!!! Skip Scanning Damages From Chem =====\n";
             fSkipScanningIndirectDamage = true;
         }
         if (fchemTables.size() > 0) {
             SortChemTableWithSelection();
         }
     } else {
         std::cout<<"=====>> Cannot find folder \""<<fChemOutFolderName<<"\"!!! Skip Scanning Damages From Chem =====\n";
         fSkipScanningIndirectDamage = true;
     }
     
     std::cout<<"===== End Scanning Damages From Chem =====\n";
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::AnaPhysRootFile(const std::string fileName)
 {
     TFile* f = new TFile(fileName.c_str());
     if(f->IsZombie() ){
         // File is corrupted
         std::cerr<<"*********** Warning *************"<<std::endl;
         std::cerr<<"The file "<<fileName<<" seems to be corrupted..."<<std::endl;
         std::cerr<<"We will skip it."<<std::endl;
         std::cerr<<"**********************************"<<std::endl;
         return;
     }
     AnaPhysRootTree1(f);
     AnaPhysRootTree2(f);
     f->Close();
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::AnaChemRootFile(fs::directory_entry entry)
 {
     std::string fnameWithoutExtension = entry.path().stem().string();
     auto [eventNumber, voxelNumber] = GetEventNberAndVoxelNberFromChemRoot(fnameWithoutExtension);
     
     // Voxel data retrieval
     VoxelData& voxelData = fVoxels.at(voxelNumber);
 
     int chromo = voxelData.fChromosome;
     ullint firstBpNum = voxelData.fFirstBpCopyNum;
     // *******************
     // Analyse of the ntuple to detect SB and associate them with a bpNumCorrected
     // *******************
 
     // Load the file, the directory and the ntuple
     TFile f(entry.path().c_str());
     if(f.IsZombie() ){
         corruptedFiles++;
         // File is corrupted
         std::cerr<<"*********** Warning *************"<<std::endl;
         std::cerr<<"The file "<<entry.path().string()<<" seems to be corrupted..."<<std::endl;
         std::cerr<<"We will skip it."<<std::endl;
         std::cerr<<"Number of corrupted files: "<< corruptedFiles<<std::endl;
         std::cerr<<"**********************************"<<std::endl;
     } else {
         TDirectoryFile *d = dynamic_cast<TDirectoryFile*> (f.Get("ntuple") );
         TTree* chemTree = (TTree*) d->Get("ntuple_2");
 
         if( (int) chemTree->GetEntries() >0)
         {
             int strand;
             int copyNumber;
             double xp;
             double yp;
             double zp;
             double time;
             int base;
             chemTree->SetBranchAddress("strand", &strand);
             chemTree->SetBranchAddress("copyNumber", &copyNumber);
             chemTree->SetBranchAddress("xp", &xp);
             chemTree->SetBranchAddress("yp", &yp);
             chemTree->SetBranchAddress("zp", &zp);
             chemTree->SetBranchAddress("time", &time);
             chemTree->SetBranchAddress("base", &base);
             unsigned int entryNumber = (int) chemTree->GetEntries();
             for (unsigned int e=0;e<entryNumber;e++)
             {
                 chemTree->GetEntry(e);
                 ullint cpNumCorrected = firstBpNum+int(copyNumber);
                 std::vector<ullint> newLine{ 
                     (ullint)eventNumber,(ullint)strand,cpNumCorrected,
                     (ullint)base,(ullint)(time*1000000)};
                 auto itr = fchemTables.find(chromo);
                 if ( itr == fchemTables.end()) {
                     Table tbforThisChro{newLine};
                     fchemTables.insert({chromo,tbforThisChro});
                 } else (itr->second).push_back(newLine);
             }
         }
     }//
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 std::tuple<unsigned int, unsigned int> ScanDamage::GetEventNberAndVoxelNberFromChemRoot(
     const std::string fileNameWithoutExtension)
 {
     unsigned int evnN, volxelN;
     auto fristPos = fileNameWithoutExtension.find_first_of("_");
     auto secondPos = fileNameWithoutExtension.substr(fristPos+1).find_first_of("_");
     auto lastPos = fileNameWithoutExtension.find_last_of("_");
     evnN = std::stoul(fileNameWithoutExtension.substr(fristPos+1,secondPos));
     volxelN = std::stoul(fileNameWithoutExtension.substr(lastPos+1));
     return  {evnN, volxelN};
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::AnaPhysRootTree1(TFile* f)
 {
     TDirectoryFile* d = dynamic_cast<TDirectoryFile*> (f->Get("ntuple") );
     TTree* tPhys = dynamic_cast<TTree*> (d->Get("ntuple_1") );
 
     if( tPhys->GetEntries()  > 0)
         {
         int flagParticle;
         int flagParentID;
         int flagProcess;
         double x;
         double y;
         double z;
         double edep;
         int eventNumber;
         int volumeName;
         int copyNumber;
         int lastMetVoxelCopyNum;
 
         tPhys->SetBranchAddress("flagParticle", &flagParticle);
         tPhys->SetBranchAddress("flagParentID", &flagParentID);
         tPhys->SetBranchAddress("flagProcess", &flagProcess);
         tPhys->SetBranchAddress("x", &x);
         tPhys->SetBranchAddress("y", &y);
         tPhys->SetBranchAddress("z", &z);
         tPhys->SetBranchAddress("edep", &edep);
         tPhys->SetBranchAddress("eventNumber", &eventNumber);
         tPhys->SetBranchAddress("volumeName", &volumeName);
         tPhys->SetBranchAddress("copyNumber", &copyNumber);
         tPhys->SetBranchAddress("lastMetVoxelCopyNum", &lastMetVoxelCopyNum);
 
         unsigned int entryNumber =  tPhys->GetEntries() ;
 
         // Loop on all the "lines" (ie entry) of the ntuple
         for(unsigned int e=0; e<entryNumber; e++)
         {
             // Set all the variables to the values corresponding to the entry number
             tPhys->GetEntry(e);
             // Check if the process is an ionisation
             // Only ionisation should trigger the removal of a DNA molecule from the chemical step
             if(flagProcess == 13 // e-_DNAIonisation
                     || flagProcess == 113 // e-_DNAPTBIonisation
                     || flagProcess == 18 // proton_DNAIonisation
                     || flagProcess == 21 // hydrogen_DNAIonisation
                     || flagProcess == 24 // alpha_DNAIonisation
                     || flagProcess == 27 // alpha+_DNAIonisation
                     || flagProcess == 31 // helium_DNAIonisation
                     || flagProcess == 12 // e-_DNAExcitation
                     || flagProcess == 112 // e-_DNAPTBExcitation
                     || flagProcess == 15 // e-_DNAVibExcitation
                     || flagProcess == 17 // proton_DNAExcitation
                     || flagProcess == 20 // hydrogen_DNAExcitation
                     || flagProcess == 23 // alpha_DNAExcitation
                     || flagProcess == 26 // alpha+_DNAExcitation
                     || flagProcess == 30 // helium_DNAExcitation
                     ) {
                 // Check the interaction happened in a dna molecule or its hydration shell
                 if(volumeName == 1 // d1
                         || volumeName == 11 // p1
                         || volumeName == 2 // d2
                         || volumeName == 22 // p2
                         || volumeName == 7 // d1_w
                         || volumeName == 71 // p1_w
                         || volumeName == 8 // d2_w
                         || volumeName == 81 // p2_w
                         )
                 {
                     // *************
 
                     // Retrieve the voxel copy number
                     double voxelCopyNumber  = lastMetVoxelCopyNum;
                     if (voxelCopyNumber >= 0 && voxelCopyNumber<fVoxels.size()){
                         // Chromosome, domain and firstNucleotideNum
                         const VoxelData& voxelData = fVoxels.at(size_t(voxelCopyNumber) );
                         int chromo = voxelData.fChromosome;
                         int domain = voxelData.fDomain;
                         ullint firstBpCN = voxelData.fFirstBpCopyNum;
                         ullint cpNumCorrected = firstBpCN+int(copyNumber);
 
                         // Get the event number
                         double eventNum = eventNumber;
 
                         // Determine the strand
                         double strand (-1);
                         if(volumeName==1
                                 || volumeName==11
                                 || volumeName==7
                                 || volumeName==71
                                 || volumeName==6 // ade
                                 || volumeName==9 // ade
                                 || volumeName==4 // gua
                                 || volumeName==10) // gua
                             strand = 1;
                         else if(volumeName==2
                                 || volumeName==22
                                 || volumeName==8
                                 || volumeName==81
                                 || volumeName==5 // thy
                                 || volumeName==12 // thy
                                 || volumeName==3 // cyto
                                 || volumeName==13) // cyto
                             strand = 2;
                         // Check if the chromo has already been registered
                         std::vector<ullint> newLine{ 
                             (ullint)eventNum,(ullint)strand,cpNumCorrected,
                             (ullint)volumeName,(ullint)flagProcess,(ullint)(edep*1000000)};
                             // *1000000 in edep is taken back after. This is done 
                             // because the number is "unsigned long long int" instead of "double".
                         auto itr = fphysTables.find(chromo);
                         if ( itr == fphysTables.end()) {
                             Table tbforThisChro{newLine};
                             fphysTables.insert({chromo,tbforThisChro});
                         } else (itr->second).push_back(newLine);
                     }
                 }
             }
         }
     }
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::AnaPhysRootTree2(TFile* f)
 {
     TDirectoryFile* d2 = dynamic_cast<TDirectoryFile*> (f->Get("ntuple") );
     TTree* tPhys2 = dynamic_cast<TTree*> (d2->Get("ntuple_3") );
 
     if( int(tPhys2->GetEntries() ) > 0)
     {
         double edep;
         int eventNumber;
 
         tPhys2->SetBranchAddress("edep", &edep);
         tPhys2->SetBranchAddress("eventNumber", &eventNumber);
 
         unsigned int entryNumber = int( tPhys2->GetEntries() );
 
         // Loop on all the "lines" (ie entry) of the ntuple
         for(unsigned int e=0; e<entryNumber; e++)
         {
             tPhys2->GetEntry(e);
             fEdepSumInNucleus += edep;
         }
     }
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::SortPhysTableWithSelection()
 {
     for(const auto [chrom, physTable] : fphysTables)
     {
         // Final table
         Table physTableWithSelection;
 
         std::map<ullint,std::map<ullint,std::map<ullint, ullint > > > energyMap;
         
         // Loop on all the lines of the table
         for(unsigned int line=0, eline=physTable.size(); line<eline; ++line)
         {
             ullint eventNum = physTable[line][0];
             ullint strand = physTable[line][1];
             ullint copyNumber = physTable[line][2];
             ullint volumeFlag = physTable[line][3];
             ullint processFlagr = physTable[line][4];
             ullint energy = physTable[line][5];
 
             // Cumulate the energy value
             energyMap[eventNum][strand][copyNumber] += energy;
         }
 
         int notDuplicatedLine = 0;
 
         // Loop on all the events
         std::map<ullint, std::map<ullint, std::map<ullint, ullint> > >::iterator iit = energyMap.begin();
         std::map<ullint, std::map<ullint, std::map<ullint, ullint> > >::iterator iite = energyMap.end();
         for(; iit!=iite;++iit)
         {
             ullint eventNum = iit->first;
 
             // Loop on all the strands
             std::map<ullint, std::map<ullint, ullint> >::iterator itt = iit->second.begin();
             std::map<ullint, std::map<ullint, ullint> >::iterator itte = iit->second.end();
             for(; itt!=itte;++itt)
             {
                 ullint strand = itt->first;
                 // Loop on all the copy numbers
                 std::map<ullint, ullint>::iterator ittt = itt->second.begin();
                 std::map<ullint, ullint>::iterator ittte = itt->second.end();
                 for(; ittt!=ittte;++ittt)
                 {
                     ullint copyNumber = ittt->first;
                     double currentE = double(ittt->second) / 1000000; // eV
                     // Energy condition(s) are set here
                     bool fill = false;                  
                      // Threshold condition
                      if(currentE < fThresholdEnergy)
                           fill=false;
                      else
                           fill=true;
 
                     if(fill)
                     {
                         // Add a line
                         physTableWithSelection.push_back(std::vector<ullint>());
                         // Fill the line
                         physTableWithSelection[notDuplicatedLine].push_back(eventNum);
                         physTableWithSelection[notDuplicatedLine].push_back(strand);
                         physTableWithSelection[notDuplicatedLine].push_back(copyNumber);
                         physTableWithSelection[notDuplicatedLine].push_back(0);
                         physTableWithSelection[notDuplicatedLine].push_back(0);
                         physTableWithSelection[notDuplicatedLine].push_back((ullint)(currentE*1000000) );
                         physTableWithSelection[notDuplicatedLine].push_back(0);
                         ++notDuplicatedLine;
                     }
                 }
             }
         }
         // *******************************************
         // Print the "physTableWithSelection" table for the current chromosome
         // *******************************************
         std::cout << "### Phys SB for chromosome "<<chrom<<" : " << physTableWithSelection.size() << " ###" << std::endl;
         if (physTableWithSelection.size()>0) fphysSlectedTables.insert({chrom,physTableWithSelection});
     }
     fphysTables.clear();//Free memory
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::SortChemTableWithSelection()
 {
     for (const auto& [chromo,chemTable] : fchemTables)
     {
         // Final table
         Table chemTableWithSelection;
         
         int notDuplicatedLine = 0;
 
         for(unsigned int line=0, eline=chemTable.size(); line<eline; ++line)
         {
             ullint eventNum = chemTable[line][0];
             ullint strand = chemTable[line][1];
             ullint copyNumber = chemTable[line][2];
             ullint base = chemTable[line][3];
             ullint time = chemTable[line][4];
         
             // Random number between 0 and <1
             if (base==1) {
                 // Add a line
                 chemTableWithSelection.push_back(std::vector<ullint>());
                 // Fill the line
                 chemTableWithSelection[notDuplicatedLine].push_back(eventNum);
                 chemTableWithSelection[notDuplicatedLine].push_back(strand);
                 chemTableWithSelection[notDuplicatedLine].push_back(copyNumber);
                 chemTableWithSelection[notDuplicatedLine].push_back(base);
                 chemTableWithSelection[notDuplicatedLine].push_back(time);
                 chemTableWithSelection[notDuplicatedLine].push_back(0);
                 chemTableWithSelection[notDuplicatedLine].push_back(1);              
                 ++notDuplicatedLine;
             }
             else { 
                 //double r = double(std::rand() ) / RAND_MAX;
                 double r = gRandomGen.Rndm(); 
                 //std::cout<<r<<std::endl;
                 if(r <= fProbabilityForIndirectSB){
                     // Add a line
                     chemTableWithSelection.push_back(std::vector<ullint>());
                     // Fill the line
                     chemTableWithSelection[notDuplicatedLine].push_back(eventNum);
                     chemTableWithSelection[notDuplicatedLine].push_back(strand);
                     chemTableWithSelection[notDuplicatedLine].push_back(copyNumber);
                     chemTableWithSelection[notDuplicatedLine].push_back(base);
                     chemTableWithSelection[notDuplicatedLine].push_back(time);
                     chemTableWithSelection[notDuplicatedLine].push_back(0);
                     chemTableWithSelection[notDuplicatedLine].push_back(1);                          
                     ++notDuplicatedLine;
                 }
             }
         }       
         if (chemTableWithSelection.size() > 0) fchemSlectedTables.insert({chromo,chemTableWithSelection});
     }
     fchemTables.clear();//free memory
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::MergeDamageFromPhysChem()
 {
     for(int  chromo=0; chromo<46; chromo++)
     {
         // *****************************
         // Add one table after the other
         // *****************************
 
         // MergedTable to be built
         Table mergedTable;
 
         auto itr = fphysSlectedTables.find(chromo);
         if(itr != fphysSlectedTables.end())
         {
             Table physTable= itr->second;
             for(auto const& vec : physTable) mergedTable.push_back(vec);
         }
         itr = fchemSlectedTables.find(chromo);
         if(itr != fchemSlectedTables.end())
         {
             Table chemTable = itr->second;
             for(auto const& vec : chemTable) mergedTable.push_back(vec);
         }
 
         // *******************************************
         // Sort the merged table to put the event in the correct order
         // *******************************************
         Trier tri;
         Table::iterator it = mergedTable.begin();
         Table::iterator ite = mergedTable.end();
         std::sort(it, ite, tri);
 
         // *******************************************
         // Delete duplicate SB
         // *******************************************
 
         std::map<ullint,std::map<ullint,std::map<ullint,std::map<ullint,std::vector<ullint>>>>> removeDuplicateValueMap;
 
         // Put all the values of the mergedTable in the map created just above.
         // Loop on all the lines of the mergedTable
         for(unsigned int line=0; line<mergedTable.size(); ++line)
         {
             ullint eventNum = mergedTable[line][0];
             ullint strand = mergedTable[line][1];
             ullint copyNumber = mergedTable[line][2];
             ullint base = mergedTable[line][3];
             std::vector<ullint> lineV;
             // If more elements are presents, add them here
             int lineSize = mergedTable[line].size();
             if(lineSize > 4)
             {
                 for(int i=4; i<lineSize; i++)
                 {
                     lineV.push_back(mergedTable[line][i]);
                 }
                 removeDuplicateValueMap[eventNum][strand][copyNumber][base]=lineV;
             }
             else
             {
                 lineV.push_back(0);
                 removeDuplicateValueMap[eventNum][strand][copyNumber][base]=lineV;
             }
         }
 
         // *******************************************
         // Create the "mergedTableWithoutDuplicatedSB" table
         // *******************************************
 
         // At this point, we have created a map named "removeDuplicateValueMap" that organized all the mergedTable content
         // AND that does not contain any duplicate because of the override caracteristic of a map.
         // Indeed, doing map[2] = "hello" followed by map[2]  = "bye" will put map[2] value to "bye" because it overrided the first "hello".
         // This is a cheap way to remove duplicates by overriding them.
 
         // The next part is dedicated to the creation of the "mergedTableWithoutDuplicatedSB" table from the "removeDuplicateValueMap" map.
         // Only the event, strand and copynumber and  will be put in this final table.
         Table mergedTableWithoutDuplicatedSB;
         Table mergedTableWithoutDuplicatedSBandbases;
         int notDuplicatedLine = 0;
         int notDuplicatedLine2= 0;
         // Loop on all the events
         std::map<ullint,std::map<ullint,std::map<ullint,std::map<ullint,std::vector<ullint>>>>>::iterator 
             iit = removeDuplicateValueMap.begin();
         std::map<ullint,std::map<ullint,std::map<ullint,std::map<ullint,std::vector<ullint>>>>>::iterator 
             iite = removeDuplicateValueMap.end();
         for(; iit!=iite;++iit)
         {
             ullint eventNum = iit->first;
             // Loop on all the strands
             std::map<ullint, std::map<ullint, std::map<ullint, std::vector<ullint > > > >::iterator 
                 itt = iit->second.begin();
             std::map<ullint, std::map<ullint, std::map<ullint, std::vector<ullint > > > >::iterator 
                 itte = iit->second.end();
             for(; itt!=itte;++itt)
             {
                 ullint strand = itt->first;
                 // Loop on all the copy numbers
                 std::map<ullint, std::map<ullint, std::vector<ullint > > >::iterator ittt = itt->second.begin();
                 std::map<ullint, std::map<ullint, std::vector<ullint > > >::iterator ittte = itt->second.end();
                 for(; ittt!=ittte;++ittt)
                 {
                     ullint copyNumber = ittt->first;                    
                     // Loop on all the base flag
                     std::map<ullint, std::vector<ullint > >::iterator itttt = ittt->second.begin();
                     std::map<ullint, std::vector<ullint > >::iterator itttte = ittt->second.end();
                     for(; itttt!=itttte;++itttt)
                     {
                         ullint base = itttt->first;
                         // Fill the table
                         if (strand>0 && strand<3)
                         {
                             // Add a line
                             mergedTableWithoutDuplicatedSB.push_back(std::vector<ullint>());                           
                             // Fill the line
                             mergedTableWithoutDuplicatedSB[notDuplicatedLine].push_back(eventNum);
                             mergedTableWithoutDuplicatedSB[notDuplicatedLine].push_back(strand);
                             mergedTableWithoutDuplicatedSB[notDuplicatedLine].push_back(copyNumber);
                             mergedTableWithoutDuplicatedSB[notDuplicatedLine].push_back(base);
                             mergedTableWithoutDuplicatedSB[notDuplicatedLine].push_back(
                                 removeDuplicateValueMap[eventNum][strand][copyNumber][base][0]);
                             mergedTableWithoutDuplicatedSB[notDuplicatedLine].push_back(
                                 removeDuplicateValueMap[eventNum][strand][copyNumber][base][1]);
                             mergedTableWithoutDuplicatedSB[notDuplicatedLine].push_back(
                                 removeDuplicateValueMap[eventNum][strand][copyNumber][base][2]);
                             ++notDuplicatedLine;                           
                             if (base==0)
                             {
                                 // Add a line
                                 mergedTableWithoutDuplicatedSBandbases.push_back(std::vector<ullint>());                              
                                 // Fill the line
                                 mergedTableWithoutDuplicatedSBandbases[notDuplicatedLine2].push_back(eventNum);
                                 mergedTableWithoutDuplicatedSBandbases[notDuplicatedLine2].push_back(strand);
                                 mergedTableWithoutDuplicatedSBandbases[notDuplicatedLine2].push_back(copyNumber);                               
                                 ++notDuplicatedLine2;
                             }
                         }
                     }
                 }
             }
         }
 
         // *******************************************
         // Print the "mergedTableWithoutDuplicatedSB" table for the current chromosome
         // *******************************************
         if (mergedTableWithoutDuplicatedSB.size() > 0) {
             //PrintTable(fMergeFolder + "/chromo_"+std::to_string(chromo)+".dat", 
             //mergedTableWithoutDuplicatedSB, "eventNum, strand, copyNumber, isbase, 
             //time(ns*1000000), edep, phy:0 chem:1");
             fMergedTables.insert({chromo,mergedTableWithoutDuplicatedSB});
         }
         mergedTable.clear();
         mergedTableWithoutDuplicatedSBandbases.clear();
         mergedTableWithoutDuplicatedSB.clear();
     }
     //free memory:
     fphysSlectedTables.clear();
     fchemSlectedTables.clear();
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....
 
 void ScanDamage::ReadCellandVoxelDefFilePaths()
 {
     fs::path thisP = fs::current_path();
     for (const auto entry : fs::directory_iterator(thisP)){
         if (entry.path().filename() == "imp.info") {
             std::ifstream file(entry.path().c_str());
             if(!file.good() ){
                 std::cerr<<"**** Fatal Error *****"<<std::endl;
                 std::cerr<<"ScanDamage::ReadCellandVoxelDefFilePaths(): File corupted: "
                 <<entry.path()<<std::endl;
                 std::cerr<<"*************** *****"<<std::endl;
                 exit(EXIT_FAILURE);
             }
 
             std::string line;
             while(std::getline(file, line) ){
                 std::istringstream iss(line);
                 std::string flag;
                 iss >> flag;
                 if ( flag == "_geovolxelpath") {
                     std::string voxname;
                     iss >> voxname;
                     fVoxelDefFilesList.insert(voxname);
                 }
                 if ( flag == "_geocellpath") {
                     std::string cellpname;
                     iss >> cellpname;
                     fCellDefFilePath = cellpname;
                 }
                 if ( flag == "_numberOfBasepairs") {
                     iss >> fTotalNbBpPlacedInGeo;
                 }
                 if ( flag == "_numberOfHistones") {
                     iss >> fTotalNbHistonePlacedInGeo;
                 }
                 if ( flag == "_nucleusVolume") {
                     iss >> fNucleusVolume;
                 }
                 if ( flag == "_nucleusMassDensity") {
                     iss >> fNucleusMassDensity;
                 }
                 if ( flag == "_nucleusMass") {
                     iss >> fNucleusMass;
                 }
             }
             file.close();
         }
     }
 }
 
 //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo.....

This page was automatically generated by the 2.3.7 LXR engine. The LXR team